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Antimicrobial Agents and Chemotherapy, August 2002, p. 2450-2457, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2450-2457.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

N-Arylsulfonyl Hydrazones as Inhibitors of IMP-1 Metallo-ß-Lactamase

Stefan Siemann,1 Darryl P. Evanoff,1 Laura Marrone,1 Anthony J. Clarke,2 Thammaiah Viswanatha,1 and Gary I. Dmitrienko1*

Department of Chemistry, University of Waterloo, Waterloo, Ontario N2L 3G1,1 Canadian Bacterial Diseases Network, Department of Microbiology, University of Guelph, Guelph, Ontario N1G 2W1, Canada2

Received 28 September 2001/ Returned for modification 12 January 2002/ Accepted 9 April 2002

Members of a family of N-arylsulfonyl hydrazones have been identified as novel inhibitors of IMP-1, a metallo-ß-lactamase of increasing prevalence. Structure-activity relationship studies have indicated a requirement for bulky aromatic substituents on each side of the sulfonyl hydrazone backbone for these compounds to serve as efficient inhibitors of IMP-1. Molecular modeling has provided insight into the structural basis for the anti-metallo-ß-lactamase activity exhibited by this class of compounds.

* Corresponding author. Mailing address: Department of Chemistry, University of Waterloo, 200 University Ave. W., Waterloo, Ontario N2L 3G1, Canada. Phone: (519) 888-4642. Fax: (519) 746-0435. E-mail: dmitrien{at}muskie.uwaterloo.ca.

Antimicrobial Agents and Chemotherapy, August 2002, p. 2450-2457, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2450-2457.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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