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Antimicrobial Agents and Chemotherapy, August 2002, p. 2640-2643, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2640-2643.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

The AcrAB-TolC Efflux Pump Contributes to Multidrug Resistance in the Nosocomial Pathogen Enterobacter aerogenes

Elizabeth Pradel* and Jean-Marie Pagès

INSERM CJF9606-EA2197, IFR48, Faculté de Médecine, 13385 Marseille Cedex 05, France

Received 21 December 2001/ Returned for modification 6 March 2002/ Accepted 2 May 2002

We identified the genes encoding the AcrA-AcrB-TolC efflux pump in Enterobacter aerogenes and constructed acrAB and tolC mutants from a multidrug-resistant isolate. Both derivatives were more susceptible to antibiotics than the parental strain. Sequence analysis and complementation experiments revealed that the multidrug-resistant isolate is an acrR mutant.

* Corresponding author: Mailing address: INSERM CJF9606, Faculté de Médecine, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France. Phone: 33 (0) 491 32 46 07. Fax: 33 (0) 491 32 46 06. E-mail: elizabeth.pradel{at}medecine.univ-mrs.fr.

Antimicrobial Agents and Chemotherapy, August 2002, p. 2640-2643, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2640-2643.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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