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Antimicrobial Agents and Chemotherapy, August 2002, p. 2668-2670, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2668-2670.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Chemiosmotic Mechanism of Antimicrobial Activity of Ag+ in Vibrio cholerae

Pavel Dibrov,1 Judith Dzioba,1 Khoosheh K. Gosink,2 and Claudia C. Häse2*

Department of Microbiology, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada,1 Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 381052

Received 4 February 2002/ Returned for modification 30 April 2002/ Accepted 17 May 2002

Although the antimicrobial effects of silver salts were noticed long ago, the molecular mechanism of the bactericidal action of Ag+ in low concentrations has not been elucidated. Here, we show that low concentrations of Ag+ induce a massive proton leakage through the Vibrio cholerae membrane, which results in complete deenergization and, with a high degree of probability, cell death.

* Corresponding author. Mailing address: Infectious Diseases, St. Jude Children's Research Hospital, 332 N. Lauderdale St., Memphis, TN 38105. Phone: (901) 495-2865. Fax: (901) 495-3099. E-mail: claudia.hase{at}stjude.org.

Antimicrobial Agents and Chemotherapy, August 2002, p. 2668-2670, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2668-2670.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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