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Antimicrobial Agents and Chemotherapy, August 2002, p. 2671-2675, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2671-2675.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Incidence, Epidemiology, and Characteristics of Quinolone- Nonsusceptible Streptococcus pneumoniae in Croatia

Glenn A. Pankuch,1 Bülent Bozdogan,1 Kensuke Nagai,1 Arjana Tambic-Andrasevic,2 Slavko Schoenwald,2 Tera Tambic,3 Smilja Kalenic,4 Sanja Plesko,2 Nastja K. Tepes,5 Zdenka Kotarski,6 Marina Payerl-Pal,7 and Peter C. Appelbaum1*

Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033,1 University Hospital of Infectious Diseases "Dr. F. Mihaljevic,",2 Croatian Academy of Medical Sciences,3 Zagreb Clinical Hospital Center,4 Sveti Duh General Hospital,5 University Hospital for Lung Diseases, Zagreb,6 Public Health Laboratory, Cakovec, Croatia7

Received 31 January 2002/ Returned for modification 30 March 2002/ Accepted 23 April 2002

Among 585 Streptococcus pneumoniae strains isolated in 22 Croatian hospitals 21 strains (3.6%) were quinolone nonsusceptible. MICs of all quinolones were high for seven strains tested with the same serotype (23F) and mutations in gyrA, parC, and parE. The remaining 14 strains were more heterogeneous and had mutations only in parC and/or parE, and the MICs of quinolones were lower for these strains.

* Corresponding author. Mailing address: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu.

Antimicrobial Agents and Chemotherapy, August 2002, p. 2671-2675, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2671-2675.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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