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Antimicrobial Agents and Chemotherapy, August 2002, p. 2676-2678, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2676-2678.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Role of Active Efflux in Association with Target Gene Mutations in Fluoroquinolone Resistance in Clinical Isolates of Vibrio cholerae

Somesh Baranwal,1 Keya Dey,2 T. Ramamurthy,2 G. Balakrish Nair,2,{dagger} and Manikuntala Kundu1*

Department of Chemistry, Bose Institute, Kolkata 700009,1 National Institute of Cholera and Enteric Diseases, Beleghata, Kolkata 700010, India2

Received 27 November 2001/ Returned for modification 12 March 2002/ Accepted 13 May 2002

Quinolones are among the drugs of choice in the management of cholera caused by Vibrio cholerae. In this study, we demonstrate that, in addition to mutations detected in the target genes gyrA and parC, proton motive force-dependent efflux is involved in quinolone resistance in clinical isolates of V. cholerae.

* Corresponding author. Mailing address: Department of Chemistry, Bose Institute, 93/1 Acharya Prafulla Chandra Rd., Kolkata 700009, India. Phone: 91 33 350 2402/3. Fax: 91 33 3506790. E-mail: mani{at}bosemain.boseinst.ac.in.

{dagger} Present address: International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.

Antimicrobial Agents and Chemotherapy, August 2002, p. 2676-2678, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2676-2678.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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