This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pilon, A. A.
Right arrow Articles by Badley, A. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pilon, A. A.
Right arrow Articles by Badley, A. D.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, August 2002, p. 2687-2691, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2687-2691.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Induction of Apoptosis by a Nonnucleoside Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitor

A. A. Pilon,1 J. J. Lum,1 J. Sanchez-Dardon,1 B. N. Phenix,1 R. Douglas,1 and A. D. Badley1,2*

Ottawa Health Research Institute, HIV Research Laboratory, Ottawa, Ontario, Canada K1H 8L6,1 Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota 559052

Received 18 December 2001/ Returned for modification 14 March 2002/ Accepted 18 April 2002

Inhibition of human immunodeficiency virus type 1 reverse transcriptase (RT) by both nucleoside and nonnucleoside RT inhibitors profoundly inhibits virus replication. Nucleoside RT inhibitors are known to be toxic, but there is little information regarding the toxicities of nonnucleoside RT inhibitors (NNRTI). We demonstrate that efavirenz (an NNRTI) induces caspase- and mitochondrion-dependent apoptosis of Jurkat T cells and human peripheral blood mononuclear cells. The clinical relevance of these observations is not yet clear.

* Corresponding author. Present address: M.D. FRCPC, Division of Infectious Diseases, Mayo Clinic and Foundation, 200 First St. NW, Rochester, MN 55905. Phone: (507) 255-7761. Fax: (507) 255-7767.

Antimicrobial Agents and Chemotherapy, August 2002, p. 2687-2691, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2687-2691.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Maagaard, A., Kvale, D. (2009). Mitochondrial toxicity in HIV-infected patients both off and on antiretroviral treatment: a continuum or distinct underlying mechanisms?. J Antimicrob Chemother 64: 901-909 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»