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Antimicrobial Agents and Chemotherapy, August 2002, p. 2700-2703, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2700-2703.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Biguanide-Atovaquone Synergy against Plasmodium falciparum In Vitro

K. Jones1 and S. A. Ward2*

Department of Pharmacology and Therapeutics, University of Liverpool,1 Liverpool School of Tropical Medicine, Liverpool, United Kingdom2

Received 19 February 2002/ Returned for modification 3 April 2002/ Accepted 24 April 2002

The synergistic potential of a range of biguanides, their triazine metabolites, tetracyclines, and pyrimethamine in combination with atovaquone has been assessed. All five biguanides tested interacted synergistically with atovaquone against Plasmodium falciparum in vitro. All of the other compounds tested were either additive or antagonistic.

* Corresponding author. Mailing address: Liverpool School of Tropical Medicine, Pembroke Pl., Liverpool L35QA, United Kingdom. Phone: 44 151 705 3286. Fax: 44 151 708 9007. E-mail: saward{at}liv.ac.uk.

Antimicrobial Agents and Chemotherapy, August 2002, p. 2700-2703, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2700-2703.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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