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Antimicrobial Agents and Chemotherapy, August 2002, p. 2708-2711, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2708-2711.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

In Vitro Susceptibilities of Zygomycetes to Combinations of Antimicrobial Agents

Eric Dannaoui,1 Javier Afeltra,1 Jacques F. G. M. Meis,2 Paul E. Verweij,1* and The Eurofung Network{dagger}

Department of Medical Microbiology, University Medical Center St. Radboud, 6500 HB Nijmegen,1 Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, 65000 GS Nijmegen, The Netherlands2

Received 16 January 2002/ Returned for modification 14 February 2002/ Accepted 30 April 2002

Combinations of antimicrobial agents were tested against 35 strains of zygomycetes. The interaction between amphotericin B and rifampin was synergistic or additive. Flucytosine alone was inactive and, upon combination with amphotericin B, synergy was not achieved. The combination of amphotericin B with terbinafine was synergistic for 20% of strains, and the interaction between terbinafine and voriconazole was synergistic for 44% of strains. Antagonism was not observed.

* Corresponding author. Mailing address: Department of Medical Microbiology, University Medical Center Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Phone: (31) 24 361 43 56. Fax: (31) 24 354 02 16. E-mail: p.verweij{at}mmb.azn.nl.

{dagger} The Eurofung Network consists of the following participants: Emmanuel Roilides, coordinator, and Nicos Maglaveras, Aristotle University, Thessaloniki, Greece; Tore Abrahamsen and Peter Gaustad, Rikshospitalet National Hospital, Oslo, Norway; David W. Denning, University of Manchester, Manchester, United Kingdom; Paul E. Verweij and Jacques F. G. M. Meis, University of Nijmegen, Nijmegen, The Netherlands; Juan L. Rodriguez-Tudela, Instituto de Salud Carlos III, Madrid, Spain; and George Petrikkos, Athens University, Athens, Greece.

Antimicrobial Agents and Chemotherapy, August 2002, p. 2708-2711, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2708-2711.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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