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Antimicrobial Agents and Chemotherapy, August 2002, p. 2716-2719, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2716-2719.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Activities of ABT-773 against Microaerophilic and Fastidious Organisms

Sydney M. Finegold,1,2,3* Denise Molitoris,4 V. T. Phan,4 M.-L. Vaisanen,4 and Hannah M. Wexler2,4

Infectious Diseases Section,1 Research Service, VA Greater Los Angeles Healthcare System, West Los Angeles Division, Los Angeles, California 90073,4 Departments of Medicine,2 Microbiology, Immunology and Molecular Genetics, UCLA School of Medicine, Los Angeles, California 900243

Received 25 June 2001/ Returned for modification 29 November 2001/ Accepted 17 April 2002

ABT-773 was tested against 317 fastidious isolates; it inhibited 99% of organisms at a concentration of 4.0 µg/ml. With ampicillin-sulbactam and levofloxacin, only 2 and 6% of these strains, respectively, were resistant at the breakpoint. With clindamycin, penicillin G, and metronidazole, 22, 26, and 58% of the strains, respectively, were resistant.

* Corresponding author. Mailing address: Infectious Diseases Section (111 F), Greater Los Angeles Healthcare System, W. L. A., Los Angeles, CA 90073. Phone: (310) 268-3678. Fax: (310) 472-7097. E-mail: sidfinegol{at}aol.com.

Antimicrobial Agents and Chemotherapy, August 2002, p. 2716-2719, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2716-2719.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Garcia, I., Pascual, A., Ballesta, S., del Castillo, C., Perea, E. J. (2003). Accumulation and activity of cethromycin (ABT-773) within human polymorphonuclear leucocytes. J Antimicrob Chemother 52: 24-28 [Abstract] [Full Text]  


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