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Antimicrobial Agents and Chemotherapy, September 2002, p. 2920-2925, Vol. 46, No. 9
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.9.2920-2925.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Consumption of Imipenem Correlates with ß-Lactam Resistance in Pseudomonas aeruginosa

Philipp M. Lepper,1 Eberhard Grusa,2 Helga Reichl,3 Josef Högel,4 and Matthias Trautmann1*

Section of Hospital Hygiene, Department of Medical Microbiology and Hygiene, Ulm University Hospital,1 Institute of Biometry and Medical Documentation, University of Ulm, Ulm,4 Clinical Pharmacy,2 Microbiological Laboratory, Klinikum Memmingen, Memmingen, Germany3

Received 20 September 2001/ Returned for modification 22 February 2001/ Accepted 4 June 2002

It is generally assumed that the antibiotic prescription policy of a hospital has a significant impact on bacterial resistance rates; however, few studies are available to support this concept with valid statistical data. During a 3-year period from 1997 to 2000, we monitored the consumption of ß-lactam and other antibiotics with known activity against Pseudomonas aeruginosa in a 600-bed community hospital. Monthly isolations of P. aeruginosa were assessed, and resistance rates were recorded. Partial correlation coefficients between consumption and resistance rates were determined, taking into account possible associations with other variables such as seasonal effects and transfers from other hospitals. A total of 30 ± 7 novel P. aeruginosa strains per month were isolated without epidemic clustering. Prescriptions of imipenem varied significantly during the study period, while prescriptions of other antipseudomonal agents were stable, with the exception of an increase in piperacillin-tazobactam prescriptions. Rates of resistance of P. aeruginosa to the antimicrobial agents used showed a time course similar to figures for imipenem consumption. Monthly rates of resistance to imipenem (partial correlation coefficient [cc], 0.63), piperacillin-tazobactam (cc, 0.57), and ceftazidime (cc, 0.56) were significantly associated with imipenem prescription rates in the same or the preceding month, while consumption of ceftazidime or piperacillin-tazobactam had no apparent association with resistance. Among the variables investigated, imipenem consumption was identified as the major factor associated with both carbapenem and ß-lactam resistance in endemic P. aeruginosa. Periods of extensive imipenem use were associated with significant increases in resistance. Our data support the concept that a written antibiotic policy which balances the use of various antibiotic classes may help to avoid disturbances of a hospital's microbial sensitivity patterns.

* Corresponding author. Present address: Institute of Hospital Hygiene, Klinikum Stuttgart, Kriegsbergstrasse 60, D-70174 Stuttgart, Germany. Phone: 49 711 278 2801. Fax: 49 711 278 2804. E-mail: m.trautmann{at}katharinenhospital.de.

Antimicrobial Agents and Chemotherapy, September 2002, p. 2920-2925, Vol. 46, No. 9
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.9.2920-2925.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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