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Antimicrobial Agents and Chemotherapy, September 2002, p. 3039-3041, Vol. 46, No. 9
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.9.3039-3041.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

In Vitro Interaction of Caspofungin Acetate with Voriconazole against Clinical Isolates of Aspergillus spp.

Sofia Perea,1* Gloria Gonzalez,2 Annette W. Fothergill,2 William R. Kirkpatrick,1 Michael G. Rinaldi,2,3 and Thomas F. Patterson1,3

Department of Medicine, Division of Infectious Diseases,1 Department of Pathology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900,2 Audie Murphy Division, South Texas Veterans Health Care System, San Antonio, Texas 78284-77503

Received 17 September 2001/ Returned for modification 29 October 2001/ Accepted 23 May 2002

The interaction between caspofungin acetate and voriconazole was studied in vitro by using 48 clinical Aspergillus spp. isolates obtained from patients with invasive aspergillosis. MICs were determined by the NCCLS broth microdilution method. Synergy, defined as a fractional inhibitory concentration (FIC) index of <1, was detected in 87.5% of the interactions; an additive effect, defined as an FIC index of 1.0, was observed in 4.2% of the interactions; and a subadditive effect, defined as an FIC index of 1.0 to 2.0, was found in 8.3% of the interactions. No antagonism was observed. Animal models are required to validate the in vivo significance of these in vitro data presented for the combination of caspofungin and voriconazole.

* Corresponding author. Mailing address: Department of Medicine, Division of Infectious Diseases, University of Texas Health Science Center, San Antonio, 7703 Floyd Curl Dr., Mail Code 7881, San Antonio, TX 78229-3900. Phone: (210) 567-1981. Fax: (210) 567-3303. E-mail: perea{at}uthscsa.edu.

Antimicrobial Agents and Chemotherapy, September 2002, p. 3039-3041, Vol. 46, No. 9
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.9.3039-3041.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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