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Antimicrobial Agents and Chemotherapy, September 2002, p. 3045-3049, Vol. 46, No. 9
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.9.3045-3049.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

ß-Lactamases of Kluyvera ascorbata, Probable Progenitors of Some Plasmid-Encoded CTX-M Types

Christel Humeniuk,1 Guillaume Arlet,2 Valerie Gautier,2 Patrick Grimont,3 Roger Labia,4 and Alain Philippon1*

Service de Bactériologie, CHU Cochin,1 Service de Bactériologie, Hôpital Tenon, UFR Saint-Antoine,2 Institut Pasteur, INSERM U389, Paris,3 Université de Brest, CNRS Unité FRE 2125, Quimper, France4

Received 24 July 2001/ Returned for modification 28 October 2001/ Accepted 7 April 2002

Kluyvera ascorbata produces a ß-lactamase that results in an atypical susceptibility pattern, including low-level resistance to penicillins, cephalothin, and cefuroxime, but this resistance is reversed by clavulanate. Ten nucleotide sequences of the corresponding gene, blaKLUA, were obtained and were found to have minor variations (96 to 100%). Otherwise, blaKLUA was found to be similar (95 to 100%) to some plasmid-encoded CTX-M-type ß-lactamases. Finally, mobilization of blaKLUA on a plasmid was found to be mediated probably by a genetic mobile element like ISEcp1.

* Corresponding author. Mailing address: Service de Bactériologie, CHU Cochin, 27 rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, France. Phone: 33 1 58 41 15 44. Fax: 33 1 58 41 15 48. E-mail: alain.philippon{at}cch.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, September 2002, p. 3045-3049, Vol. 46, No. 9
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.9.3045-3049.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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