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Antimicrobial Agents and Chemotherapy, September 2002, p. 3068-3070, Vol. 46, No. 9
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.9.3068-3070.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of Garenoxacin (BMS-284756) against 170 Clinical Isolates of Nine Pasteurella Species

Ellie J. C. Goldstein,* Diane M. Citron, C. Vreni Merriam, Yumi A. Warren, Kerin L. Tyrrell, and Helen T. Fernandez

R. M. Alden Research Laboratory, Santa Monica-University of California, Los Angeles, Medical Center, Santa Monica, California 90404, and University of California, Los Angeles, School of Medicine, Los Angeles, California 90073

Received 12 November 2001/ Returned for modification 28 March 2002/ Accepted 21 May 2002

The in vitro susceptibilities of 170 clinical isolates plus 12 American Type Culture Collection strains of Pasteurella species comprising nine species and three Pasteurella multocida subspecies were studied by an agar dilution method. Garenoxacin (BMS-284756), a new des-fluoro(6) quinolone, was active at <=0.06 µg/ml against all isolates, including four ß-lactamase-producing strains, with >90% of the strains susceptible to <=0.008 µg/ml. Garenoxacin was generally 1 to 2 dilutions more active than levofloxacin and moxifloxacin and was the most active agent tested. Cefoxitin required 1 µg/ml for inhibition of 51 of 182 (29%) of strains, and 3 strains (also ß-lactamase producers) were resistant to doxycycline.

* Corresponding author. Mailing address: 2021 Santa Monica Blvd., Suite 740 East, Santa Monica, CA 90404. Phone: (310) 315-1511. Fax: (310) 315-3662. E-mail: EJCGMD{at}aol.com.

Antimicrobial Agents and Chemotherapy, September 2002, p. 3068-3070, Vol. 46, No. 9
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.9.3068-3070.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Citron, D. M., Warren, Y. A., Fernandez, H. T., Goldstein, M. A., Tyrrell, K. L., Goldstein, E. J. C. (2005). Broth Microdilution and Disk Diffusion Tests for Susceptibility Testing of Pasteurella Species Isolated from Human Clinical Specimens. J. Clin. Microbiol. 43: 2485-2488 [Abstract] [Full Text]  


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