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Antimicrobial Agents and Chemotherapy, September 2002, p. 3088-3090, Vol. 46, No. 9
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.9.3088-3090.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Incidence of High-Level Evernimicin Resistance in Enterococcus faecium among Food Animals and Humans

Frank Møller Aarestrup1* and Paul M. McNicholas2

Danish Veterinary Institute, DK-1790 Copenhagen V, Denmark,1 Schering-Plough Research Institute, Kenilworth, New Jersey 070332

Received 28 March 2002/ Returned for modification 21 May 2002/ Accepted 12 June 2002

Six high-level evernimicin-resistant Enterococcus faecium isolates were identified among 304 avilamycin-resistant E. faecium isolates from animals and 404 stool samples from humans with diarrhea. All four animal isolates, and one of the human isolates, were able to transfer resistance to a susceptible E. faecium strain. The resulting transconjugants all tested positive for the presence of emtA, a gene encoding a methyltransferase previously linked with high-level evernimicin resistance. The four transconjugants derived from animal isolates all carried the same plasmid, while a differently sized plasmid was found in the isolate from humans. This study demonstrated a low incidence of high-level evernimicin resistance mediated by the emtA gene in different E. faecium isolates of animal and human origin.

* Corresponding author. Mailing address: Danish Veterinary Institute, 27 Bülowsvej, DK-1790 Copenhagen V, Denmark. Phone: 45 35 30 01 00. Fax: 45 35 30 01 20. E-mail: faa{at}vetinst.dk.

Antimicrobial Agents and Chemotherapy, September 2002, p. 3088-3090, Vol. 46, No. 9
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.9.3088-3090.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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