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Antimicrobial Agents and Chemotherapy, January 2003, p. 398-399, Vol. 47, No. 1
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.1.398-399.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Comparison of Linezolid Activities under Aerobic and Anaerobic Conditions against Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococcus faecium

Brent W. Gunderson,¹ Khalid H. Ibrahim,¹ Charles A. Peloquin,² Laurie B. Hovde,¹ and John C. Rotschafer^1*

Department of Experimental and Clinical Pharmacology, The University of Minnesota College of Pharmacy, Minneapolis, Minnesota,¹ Infectious Disease Pharmacokinetics Laboratory, National Jewish Medical and Research Center, Denver, Colorado²

Received 4 February 2002/ Returned for modification 2 July 2002/ Accepted 18 September 2002

Methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium were exposed to linezolid (MIC of 2 mg/liter) under aerobic or anaerobic conditions in an in vitro pharmacodynamic model. Drug concentration and half-life were adjusted to simulate clinical dosing (600 mg twice daily) of linezolid. Linezolid produced a 2-log₁₀ killing at 24 h, and rates of killing against each of these facultative organisms as measured by mean survival time appeared similar under aerobic and anaerobic conditions.

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* Corresponding author. Mailing address: University of Minnesota College of Pharmacy, Department of Experimental and Clinical Pharmacology, 7-170 Weaver-Densford Hall, 308 Harvard St. SE, Minneapolis, MN 55455. Phone: (612) 624-2183. Fax: (612) 625-9931. E-mail: rotsc001{at}umn.edu.

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Antimicrobial Agents and Chemotherapy, January 2003, p. 398-399, Vol. 47, No. 1
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.1.398-399.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

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