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Antimicrobial Agents and Chemotherapy, October 2003, p. 3323-3325, Vol. 47, No. 10
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.10.3323-3325.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

DNA Gyrase and Topoisomerase IV Mutations in Clinical Isolates of Ureaplasma spp. and Mycoplasma hominis Resistant to Fluoroquinolones

C. M. Bébéar,* H. Renaudin, A. Charron, M. Clerc, S. Pereyre, and C. Bébéar

Laboratoire de Bactériologie, Université Victor Segalen Bordeaux 2, 33076 Bordeaux, France

Received 27 March 2003/ Returned for modification 6 May 2003/ Accepted 3 July 2003

Twelve clinical isolates of Ureaplasma spp. and one isolate of Mycoplasma hominis were examined for resistance to fluoroquinolones. Previously described mutations at positions 83 and 95 in GyrA (Escherichia coli numbering) and positions 80 and 87 in ParC were found. Unusual alterations were described at positions ParC 123 and 134.

* Corresponding author. Mailing address: Laboratoire de Bactériologie, Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France. Phone: (33) 5.57.57.16.25. Fax: (33) 5.56.93.29.40. E-mail: cecile.bebear{at}u-bordeaux2.fr.

Antimicrobial Agents and Chemotherapy, October 2003, p. 3323-3325, Vol. 47, No. 10
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.10.3323-3325.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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