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Antimicrobial Agents and Chemotherapy, October 2003, p. 3349-3351, Vol. 47, No. 10
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.10.3349-3351.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Activity of Human ß-Defensin 3 Alone or Combined with Other Antimicrobial Agents against Oral Bacteria

Giuseppantonio Maisetta,1 Giovanna Batoni,1* Semih Esin,1 Filippo Luperini,1 Manuela Pardini,1 Daria Bottai,1 Walter Florio,1 Maria Rita Giuca,2 Mario Gabriele,2 and Mario Campa1

Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia,1 Dipartimento di Neuroscienze, University of Pisa, 56127 Pisa, Italy2

Received 21 February 2003/ Returned for modification 8 May 2003/ Accepted 3 July 2003

The in vitro activities of human ß-defensin 3 (hBD-3) alone or combined with lysozyme, metronidazole, amoxicillin, and chlorhexidine were investigated with the oral bacteria Streptococcus mutans, Streptococcus sanguinis, Streptococcus sobrinus, Lactobacillus acidophilus, Actinobacillus actinomycetemcomitans, and Porphyromonas gingivalis. hBD-3 showed bactericidal activity against all of the bacterial species tested. The bactericidal effect was enhanced when the peptide was used in combination with the antimicrobial agents mentioned above.

* Corresponding author. Mailing address: Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia, Via San Zeno 35-39, 56127 Pisa, Italy. Phone: 39-050-2213694. Fax: 39-050-2213771. E-mail: batoni{at}biomed.unipi.it.

Antimicrobial Agents and Chemotherapy, October 2003, p. 3349-3351, Vol. 47, No. 10
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.10.3349-3351.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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