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Antimicrobial Agents and Chemotherapy, November 2003, p. 3605-3609, Vol. 47, No. 11
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.11.3605-3609.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

First Streptococcus agalactiae Isolates Highly Resistant to Quinolones, with Point Mutations in gyrA and parC

Yoshiaki Kawamura,1* Hiromitsu Fujiwara,2 Noriko Mishima,1 Yuko Tanaka,2 Ayako Tanimoto,2 Shiro Ikawa,3 Youko Itoh,1 and Takayuki Ezaki1

Department of Microbial-Bioinformatics, Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu 500-8705,1 Department of Clinical Laboratories, Tottori University Hospital,2 Division of Clinical Laboratory Medicine, Department of Pathophysiological and Therapeutic Science, Tottori University Faculty of Medicine, Yonago 683-8504, Japan3

Received 19 March 2003/ Returned for modification 15 June 2003/ Accepted 24 July 2003

Three isolates of Streptococcus agalactiae highly resistant to multiple fluoroquinolones were isolated in Japan. Compared with susceptible strains of S. agalactiae, these quinolone-resistant strains had double point mutations within the quinolone resistance-determining regions of gyrA and parC; Ser-81 was changed to Leu (TCA -> TTA) in the amino acid sequence deduced from gyrA, and Ser-79 was changed to Phe (TCC -> TTC) in the amino acid sequence deduced from parC. Comparative sequence analysis revealed the possibility of gene transfer between S. agalactiae and another beta-hemolytic streptococcus, Streptococcus difficile.

* Corresponding author. Mailing address: Department of Microbial-Bioinformatics, Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, 40 Tsukasa-machi, Gifu 500-8705, Japan. Phone: 81-58-267-2240. Fax: 81-58-267-0156. E-mail: kawamura{at}cc.gifu-u.ac.jp.

Antimicrobial Agents and Chemotherapy, November 2003, p. 3605-3609, Vol. 47, No. 11
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.11.3605-3609.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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