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Antimicrobial Agents and Chemotherapy, November 2003, p. 3637-3639, Vol. 47, No. 11
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.11.3637-3639.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Genetic Relatedness of Recently Collected Spanish Respiratory Tract Streptococcus pneumoniae Isolates with Reduced Susceptibility to Amoxicillin

E. Pérez-Trallero,1* J. M. Marimón,1 A. González,1 C. García-Rey,2 and L. Aguilar2

Microbiology Department, Hospital Donostia, San Sebastián,1 Medical Department, GlaxoSmithKline, Tres Cantos, Madrid, Spain2

Received 10 April 2003/ Returned for modification 10 July 2003/ Accepted 22 August 2003

Of Streptococcus pneumoniae isolates from 17 hospitals, 9.8% were amoxicillin nonsusceptible (MIC >= 4 µg/ml). The genetic relatedness of 138 isolates was studied by pulsed-field gel electrophoresis. Although 44 different clones were detected, more than 62% of these isolates were related to four clones (Spain23F-1, Spain6B-2, Spain9V-3, and Spain14-5).

* Corresponding author. Mailing address: Servicio de Microbiología, Hospital Donostia, Paseo Dr. Beguiristain s/n, 20014 San Sebastián, Spain. Phone: 34 94 300 7046. Fax: 34 94 300 7063. E-mail: mikrobiol{at}terra.es.

Antimicrobial Agents and Chemotherapy, November 2003, p. 3637-3639, Vol. 47, No. 11
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.11.3637-3639.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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