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Antimicrobial Agents and Chemotherapy, November 2003, p. 3663-3666, Vol. 47, No. 11
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.11.3663-3666.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Simulation of Human Gentamicin Pharmacokinetics in an Experimental Enterococcus faecalis Endocarditis Model

Laurent Dubé,1,2 Jocelyne Caillon,1 Christèle Gras-Le Guen,1 Cédric Jacqueline,1 Marie-France Kergueris,3 Jean-Claude Granry,2 Gilles Potel,1* and Denis Bugnon1

Laboratoire d'Antibiologie, Unité UPRES EA 1156, Faculté de Médecine, F44035 Nantes Cedex 01,1 Laboratoire de Pharmacologie et de Toxicologie, CHU Nantes, 44000 Nantes,3 Department of Anesthesiology, CHU Angers, 49033 Angers, France2

Received 31 March 2003/ Returned for modification 30 May 2003/ Accepted 31 July 2003

Significant differences between animal and human pharmacokinetics may be responsible for the conflicting results of experimental studies. This study determined the impact of human pharmacokinetic simulation (HPS) on gentamicin activity in an Enterococcus faecalis endocarditis model. The decrease in bacterial counts was greater with HPS than with a dose-equivalent regimen without HPS.

* Corresponding author. Mailing address: Laboratoire d'Antibiologie Clinique et Expérimentale, Unité UPRES EA 1156, Faculté de Médecine, 1 Rue G Veil, F44035 Nantes Cedex 01, France. Phone/fax: (33) 2 40412854. E-mail: gpotel{at}sante.univ-nantes.fr.

Antimicrobial Agents and Chemotherapy, November 2003, p. 3663-3666, Vol. 47, No. 11
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.11.3663-3666.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Moreillon, P., Wilson, W. R., Leclercq, R., Entenza, J. M. (2007). Single-Dose Oral Amoxicillin or Linezolid for Prophylaxis of Experimental Endocarditis Due to Vancomycin-Susceptible and Vancomycin-Resistant Enterococcus faecalis. Antimicrob. Agents Chemother. 51: 1661-1665 [Abstract] [Full Text]  


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