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Antimicrobial Agents and Chemotherapy, December 2003, p. 3942-3944, Vol. 47, No. 12
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.12.3942-3944.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Single and Double Mutations in gyrA but Not in gyrB Are Associated with Low- and High-Level Fluoroquinolone Resistance in Helicobacter pylori

Jacques Tankovic,1* Christine Lascols,2 Quentin Sculo,2 Jean-Claude Petit,1 and Claude-James Soussy2

Laboratoire de Bactériologie, Centre Hospitalo-Universitaire Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Université Paris VI, Paris,1 Laboratoire de Bactériologie, Centre Hospitalo-Universitaire Henri-Mondor, Assistance Publique-Hôpitaux de Paris, Université Paris XII, Créteil,France2

Received 5 August 2003/ Returned for modification 3 September 2003/ Accepted 9 September 2003

In one French hospital the rate of resistance to ciprofloxacin in Helicobacter pylori was 3.3% (2 of 60 strains) in 1999. The six resistant clinical strains (four from 1996 and two from 1999) and three ciprofloxacin-selected single-step mutants studied carried one gyrA mutation but none in gyrB. Clinafloxacin and garenoxacin were the most active fluoroquinolones against these mutants. Occurrence of a second gyrA mutation was associated with high MICs of all fluoroquinolones tested.

* Corresponding author. Mailing address: Laboratoire de Bactériologie, Hôpital Saint-Antoine, 184 rue du Faubourg Saint-Antoine, 75571 Paris Cedex 12, France. Phone: 33 1 49 28 29 10. Fax: 33 1 49 28 24 72. E-mail: jacques.tankovic{at}sat.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, December 2003, p. 3942-3944, Vol. 47, No. 12
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.12.3942-3944.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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