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Antimicrobial Agents and Chemotherapy, December 2003, p. 3950-3953, Vol. 47, No. 12
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.12.3950-3953.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Structures, Locations, and Transfer Frequencies of Genetic Elements Conferring High-Level Gentamicin Resistance in Enterococcus faecalis Isolates in Greece

George L. Daikos,1* George Bamias,1 Christos Kattamis,2 Marcus J. Zervos,3 Joseph W. Chow,4 George Christakis,5 George Petrikkos,1 Penelope Triantafyllopoulou,1 Helen Alexandrou,2 and Vassiliki Syriopoulou2

First Department of Propaedeutic Medicine,1 First Department of Pediatrics, Athens University, Athens,2 Department of Clinical Microbiology, Metaxa Hospital, Piraeus,Greece,5 Department of Medicine, William Beaumont Hospital, Royal Oak,3 Division of Infectious Diseases, Wayne State University School of Medicine,Detroit, Michigan4

Received 17 April 2003/ Returned for modification 28 July 2003/ Accepted 4 September 2003

The elements conferring high-level gentamicin resistance in 64 clinical isolates of Enterococcus faecalis were characterized by PCR and by restriction enzyme hybridization analysis of genomic and plasmid DNA. There was a strong association between gentamicin resistance and the aac(6')-aph(2") gene carried on IS256-based elements with different structures, locations, and transfer characteristics.

* Corresponding author. Mailing address: First Department of Propaedeutic Medicine, Laiko General Hospital, Aghiou Thoma 17 & Alexandroupoleos, Goudi-Athens 115-26, Greece. Phone: 30-2107462636. Fax: 30-2107462635. E-mail: gdaikos{at}med.uoa.gr.

Antimicrobial Agents and Chemotherapy, December 2003, p. 3950-3953, Vol. 47, No. 12
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.12.3950-3953.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Li, C.-R., Yang, X.-Y., Lou, R.-H., Zhang, W.-X., Wang, Y.-M., Yuan, M., Li, Y., Chen, H.-Z., Hong, B., Sun, C.-H., Zhao, L.-X., Li, Z.-R., Jiang, J.-D., You, X.-F. (2008). In Vitro Antibacterial Activity of Vertilmicin and Its Susceptibility to Modifications by the Recombinant AAC(6')-APH(2'') Enzyme. Antimicrob. Agents Chemother. 52: 3875-3882 [Abstract] [Full Text]  


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