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Antimicrobial Agents and Chemotherapy, December 2003, p. 3954-3959, Vol. 47, No. 12
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.12.3954-3959.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Plasmid Content of a Vancomycin-Resistant Enterococcus faecalis Isolate from a Patient Also Colonized by Staphylococcus aureus with a VanA Phenotype

Susan E. Flannagan,1 Joseph W. Chow,2,3 Susan M. Donabedian,4 William J. Brown,5,6 Mary B. Perri,4 Marcus J. Zervos,2,4,7 Yoshiyuki Ozawa,1 and Don B. Clewell1,8*

Department of Biologic and Materials Sciences, School of Dentistry,1 Department of Microbiology and Immunology, School of Medicine, The University of Michigan, Ann Arbor, Michigan 48109,8 Division of Infectious Diseases,2 Department of Pathology,Wayne State University School of Medicine,5 Detroit Medical Center University Laboratories,6 John D. Dingell VA Medical Center, Detroit, Michigan 48201,3 Division of Infectious Disease, Department of Medicine,7 Research Institute, William Beaumont Hospital, Royal Oak, Michigan 480734

Received 19 June 2003/ Returned for modification 24 August 2003/ Accepted 10 September 2003

Vancomycin-resistant Enterococcus faecalis coisolated with vancomycin-resistant (VanA) Staphylococcus aureus was found to contain two plasmids, designated pAM830 (45 kb) and pAM831 (95 kb). pAM830, found to be conjugative and closely related to the Inc18 family of broad-host-range conjugative plasmids, encodes resistances to vancomycin (via a Tn1546-like element) and erythromycin; pAM831 encodes resistances to gentamicin, streptomycin, and erythromycin.

* Corresponding author. Mailing address: Department of Biologic and Materials Sciences, The University of Michigan School of Dentistry, 1011 N. University Ave., Ann Arbor, MI 48109-1078. Phone: (734) 763-0117. Fax: (734) 763-9905. E-mail: dclewell{at}umich.edu.

Antimicrobial Agents and Chemotherapy, December 2003, p. 3954-3959, Vol. 47, No. 12
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.12.3954-3959.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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