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Antimicrobial Agents and Chemotherapy, December 2003, p. 3960-3963, Vol. 47, No. 12
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.12.3960-3963.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Bactericidal Activities of Daptomycin, Quinupristin-Dalfopristin, and Linezolid against Vancomycin-Resistant Staphylococcus aureus in an In Vitro Pharmacodynamic Model with Simulated Endocardial Vegetations

Raymond Cha,1,2 William J. Brown,2,3 and Michael J. Rybak1,2,4*

Anti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences,1 School of Medicine,2 DMC University Laboratories,3 Detroit Receiving Hospital,Wayne State University, Detroit, Michigan 482014

Received 25 February 2003/ Returned for modification 17 April 2003/ Accepted 25 August 2003

In search of treatment alternatives against vancomycin-resistant S. aureus (VRSA), an in vitro pharmacodynamic model with simulated endocardial vegetations incorporating protein and a high inoculum was used to simulate daptomycin, linezolid, quinupristin-dalfopristin, and vancomycin against the Michigan VRSA strain. Daptomycin and quinupristin-dalfopristin exhibited the greatest bacterial reductions, and all tested agents except vancomycin exhibited bactericidal activity against the VRSA.

* Corresponding author. Mailing address: Anti-Infective Research Laboratory, Pharmacy Practice—4148, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Ave., Detroit, MI 48201. Phone: (313) 993-4673. Fax: (313) 577-8915. E-mail: m.rybak{at}wayne.edu.

Antimicrobial Agents and Chemotherapy, December 2003, p. 3960-3963, Vol. 47, No. 12
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.12.3960-3963.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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