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Antimicrobial Agents and Chemotherapy, December 2003, p. 3967-3969, Vol. 47, No. 12
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.12.3967-3969.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

In Vitro Activity of Tigecycline against Staphylococcus epidermidis Growing in an Adherent-Cell Biofilm Model

Pornpen Labthavikul, Peter J. Petersen,* and Patricia A. Bradford

Infectious Disease Research, Wyeth, Pearl River, New York 10965

Received 19 February 2003/ Returned for modification 3 July 2003/ Accepted 30 August 2003

The activity of tigecycline against Staphylococcus epidermidis growing in an in vitro adherent-cell biofilm model was determined. Tigecycline minimum bactericidal concentrations (MBCs) ranged from 1 to 8 µg/ml for S. epidermidis growing in a biofilm of adherent cells, compared to MBCs of 0.12 to >32 µg/ml for freely growing cells. The killing activity of tigecycline against the adherent bacteria was at least fourfold better than that of vancomycin and daptomycin.

* Corresponding author. Mailing address: Infectious Disease Research, Wyeth Research, Bldg. 200, Rm. 3301, 401 N. Middletown Rd., Pearl River, NY 10965. Phone: (845) 602-3070. Fax: (845) 602-5671. E-mail: petersp{at}wyeth.com.

Antimicrobial Agents and Chemotherapy, December 2003, p. 3967-3969, Vol. 47, No. 12
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.12.3967-3969.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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