This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wang, H.
Right arrow Articles by Quinn, J. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wang, H.
Right arrow Articles by Quinn, J. P.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, February 2003, p. 790-793, Vol. 47, No. 2
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.2.790-793.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Clinical Isolates of Enterobacteriaceae Producing Extended-Spectrum ß-Lactamases: Prevalence of CTX-M-3 at a Hospital in China

Hui Wang,1 Swathi Kelkar,2 Weiyuan Wu,1 Minjun Chen,1* and John P. Quinn2

Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China,1 Department of Medicine, University of Illinois, Chicago, Illinois 606122

Received 14 May 2002/ Returned for modification 17 August 2002/ Accepted 10 November 2002

The prevalence of extended-spectrum ß-lactamase-producing strains was demonstrated in 5 of 44 (11.4%) Escherichia coli, 17 of 43 (39.5%) Klebsiella pneumoniae, 3 of 50 (6.0%) Enterobacter cloacae, and 2 of 25 (8.0%) Citrobacter freundii strains at a teaching hospital in China. Nineteen of these 27 strains expressed CTX-M-3 ß-lactamase (pI 8.6). A subset of the clinical isolates expressing the CTX-M-3 enzyme, tested by pulsed-field gel electrophoresis, revealed multiple clones. Five isolates expressed a novel enzyme, SHV-43 (pI 8.0), which had two substitutions (Leu113Phe and Thr149Ser) compared with SHV-1.

* Corresponding author. Mailing address: Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China. Phone: 86-10-6529-5415. Fax: 86-10-6512-4875. E-mail: chmj_pub2{at}95777.com.

Antimicrobial Agents and Chemotherapy, February 2003, p. 790-793, Vol. 47, No. 2
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.2.790-793.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Liu, W., Chen, L., Li, H., Duan, H., Zhang, Y., Liang, X., Li, X., Zou, M., Xu, L., Hawkey, P. M. (2009). Novel CTX-M {beta}-lactamase genotype distribution and spread into multiple species of Enterobacteriaceae in Changsha, Southern China. J Antimicrob Chemother 63: 895-900 [Abstract] [Full Text]  
  • Yang, H., Chen, H., Yang, Q., Chen, M., Wang, H. (2008). High Prevalence of Plasmid-Mediated Quinolone Resistance Genes qnr and aac(6')-Ib-cr in Clinical Isolates of Enterobacteriaceae from Nine Teaching Hospitals in China. Antimicrob. Agents Chemother. 52: 4268-4273 [Abstract] [Full Text]  
  • Wang, H., Guo, P., Sun, H., Wang, H., Yang, Q., Chen, M., Xu, Y., Zhu, Y. (2007). Molecular Epidemiology of Clinical Isolates of Carbapenem-Resistant Acinetobacter spp. from Chinese Hospitals. Antimicrob. Agents Chemother. 51: 4022-4028 [Abstract] [Full Text]  
  • Ensor, V. M., Livermore, D. M., Hawkey, P. M. (2007). A novel reverse-line hybridization assay for identifying genotypes of CTX-M-type extended-spectrum {beta}-lactamases. J Antimicrob Chemother 59: 387-395 [Abstract] [Full Text]  
  • Novais, A., Canton, R., Moreira, R., Peixe, L., Baquero, F., Coque, T. M. (2007). Emergence and Dissemination of Enterobacteriaceae Isolates Producing CTX-M-1-Like Enzymes in Spain Are Associated with IncFII (CTX-M-15) and Broad-Host-Range (CTX-M-1, -3, and -32) Plasmids. Antimicrob. Agents Chemother. 51: 796-799 [Abstract] [Full Text]  
  • Ramdani-Bouguessa, N., Mendonca, N., Leitao, J., Ferreira, E., Tazir, M., Canica, M. (2006). CTX-M-3 and CTX-M-15 Extended-Spectrum {beta}-Lactamases in Isolates of Escherichia coli from a Hospital in Algiers, Algeria. J. Clin. Microbiol. 44: 4584-4586 [Abstract] [Full Text]  
  • Lolans, K., Rice, T. W., Munoz-Price, L. S., Quinn, J. P. (2006). Multicity Outbreak of Carbapenem-Resistant Acinetobacter baumannii Isolates Producing the Carbapenemase OXA-40.. Antimicrob. Agents Chemother. 50: 2941-2945 [Abstract] [Full Text]  
  • Virginia Villegas, M., Lolans, K., Correa, A., Jose Suarez, C., Lopez, J. A., Vallejo, M., Quinn, J. P., the Colombian Nosocomial Resistance Study Group, (2006). First Detection of the Plasmid-Mediated Class A Carbapenemase KPC-2 in Clinical Isolates of Klebsiella pneumoniae from South America.. Antimicrob. Agents Chemother. 50: 2880-2882 [Abstract] [Full Text]  
  • al Naiemi, N., Bart, A., de Jong, M. D., Vandenbroucke-Grauls, C. M., Rietra, P. J. G. M., Debets-Ossenkopp, Y. J., Wever, P. C., Spanjaard, L., Bos, A. J., Duim, B. (2006). Widely Distributed and Predominant CTX-M Extended-Spectrum {beta}-Lactamases in Amsterdam, The Netherlands.. J. Clin. Microbiol. 44: 3012-3014 [Abstract] [Full Text]  
  • Valverde, A., Canton, R., Galan, J. C., Nordmann, P., Baquero, F., Coque, T. M. (2006). In117, an Unusual In0-Like Class 1 Integron Containing CR1 and blaCTX-M-2 and Associated with a Tn21-Like Element. Antimicrob. Agents Chemother. 50: 799-802 [Abstract] [Full Text]  
  • Paterson, D. L., Bonomo, R. A. (2005). Extended-Spectrum {beta}-Lactamases: a Clinical Update. Clin. Microbiol. Rev. 18: 657-686 [Abstract] [Full Text]  
  • Wei, Z.-Q., Chen, Y.-G., Yu, Y.-S., Lu, W.-X., Li, L.-J. (2005). Nosocomial spread of multi-resistant Klebsiella pneumoniae containing a plasmid encoding multiple {beta}-lactamases. J Med Microbiol 54: 885-888 [Abstract] [Full Text]  
  • Ho, P. L., Ho, A. Y. M., Chow, K. H., Wong, R. C. W., Duan, R. S., Ho, W. L., Mak, G. C., Tsang, K. W., Yam, W. C., Yuen, K. Y. (2005). Occurrence and molecular analysis of extended-spectrum {beta}-lactamase-producing Proteus mirabilis in Hong Kong, 1999-2002. J Antimicrob Chemother 55: 840-845 [Abstract] [Full Text]  
  • Batchelor, M., Hopkins, K., Threlfall, E. J., Clifton-Hadley, F. A., Stallwood, A. D., Davies, R. H., Liebana, E. (2005). blaCTX-M Genes in Clinical Salmonella Isolates Recovered from Humans in England and Wales from 1992 to 2003. Antimicrob. Agents Chemother. 49: 1319-1322 [Abstract] [Full Text]  
  • Ho, P. L., Shek, R. H. L., Chow, K. H., Duan, R. S., Mak, G. C., Lai, E. L., Yam, W. C., Tsang, K. W., Lai, W. M. (2005). Detection and characterization of extended-spectrum {beta}-lactamases among bloodstream isolates of Enterobacter spp. in Hong Kong, 2000-2002. J Antimicrob Chemother 55: 326-332 [Abstract] [Full Text]  
  • Naumiuk, L., Baraniak, A., Gniadkowski, M., Krawczyk, B., Rybak, B., Sadowy, E., Samet, A., Kur, J. (2004). Molecular Epidemiology of Serratia marcescens in Two Hospitals in Danzig, Poland, over a 5-Year Period. J. Clin. Microbiol. 42: 3108-3116 [Abstract] [Full Text]  
  • Villegas, M. V., Correa, A., Perez, F., Zuluaga, T., Radice, M., Gutkind, G., Casellas, J. M., Ayala, J., Lolans, K., Quinn, J. P., the Colombian Nosocomial Resistance Study Group,, (2004). CTX-M-12 {beta}-Lactamase in a Klebsiella pneumoniae Clinical Isolate in Colombia. Antimicrob. Agents Chemother. 48: 629-631 [Abstract] [Full Text]  
  • Bonnet, R. (2004). Growing Group of Extended-Spectrum {beta}-Lactamases: the CTX-M Enzymes. Antimicrob. Agents Chemother. 48: 1-14 [Full Text]  
  • Pagani, L., Dell'Amico, E., Migliavacca, R., D'Andrea, M. M., Giacobone, E., Amicosante, G., Romero, E., Rossolini, G. M. (2003). Multiple CTX-M-Type Extended-Spectrum {beta}-Lactamases in Nosocomial Isolates of Enterobacteriaceae from a Hospital in Northern Italy. J. Clin. Microbiol. 41: 4264-4269 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»