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Antimicrobial Agents and Chemotherapy, March 2003, p. 1140-1142, Vol. 47, No. 3
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.3.1140-1142.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Postantibiotic Effects of Garenoxacin (BMS-284756) against 12 Gram-Positive or -Negative Organisms

G. A. Pankuch,1 M. R. Jacobs,2 and P. C. Appelbaum1*

Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033,1 Department of Pathology, Case Western Reserve University, Cleveland, Ohio 441062

Received 24 July 2002/ Returned for modification 24 November 2002/ Accepted 16 December 2002

Conventional in vitro methods were used to determine the postantibiotic effects (PAEs), sub-MIC effects (SMEs), and postantibiotic sub-MIC effects (PA-SMEs) of garenoxacin for a range of organisms. The mean PAEs of garenoxacin for pneumococci, staphylococci, and enterococci were 0.3 to 2.2 h. For Escherichia coli and Pseudomonas aeruginosa, the PAEs were 0.9 to 1.6 h. The mean PA-SMEs (0.4 times the MIC) for pneumococci, staphylococci, and enterococci were 3.0 to >10 h, 1.8 to >10.7 h, and 5.8 h, respectively, while those for E. coli and P. aeruginosa were 7.6 and 4.4 h, respectively.

* Corresponding author. Mailing address: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu.

Antimicrobial Agents and Chemotherapy, March 2003, p. 1140-1142, Vol. 47, No. 3
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.3.1140-1142.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Pankuch, G. A., Appelbaum, P. C. (2005). Postantibiotic Effect of DX-619 against 16 Gram-Positive Organisms. Antimicrob. Agents Chemother. 49: 3963-3965 [Abstract] [Full Text]  


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