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Antimicrobial Agents and Chemotherapy, March 2003, p. 1143-1147, Vol. 47, No. 3
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.3.1143-1147.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Antianaerobe Activity of RBX 7644 (Ranbezolid), a New Oxazolidinone, Compared with Those of Eight Other Agents

Lois M. Ednie,1 Ashok Rattan,2 Michael R. Jacobs,3 and P. C. Appelbaum1*

Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033,1 Ranbaxy Research Laboratories, New Delhi, India,2 Department of Pathology, Case Western Reserve University, Cleveland, Ohio 441063

Received 4 October 2002/ Returned for modification 2 December 2002/ Accepted 18 December 2002

The activity of ranbezolid (RBX 7644), a new oxazolidinone, against 306 anaerobes was compared with those of 11 other agents. The MICs at which 50% of the isolates tested are inhibited and those at which 90% of the isolates tested are inhibited (in micrograms per milliliter) were as follows: ranbezolid, 0.03 and 0.5; linezolid, 2 and 4; vancomycin, >16 and >16; teicoplanin, 1 and >16; quinupristin-dalfopristin, 1 and >8; amoxicillin-clavulanate, 0.5 and 2; imipenem, 0.125 and 1; clindamycin, 0.25 and 8; metronidazole, 1 and 4; gatifloxacin, 0.5 and 4; and moxifloxacin, 0.5 and 2, respectively. Ranbezolid had very good in vitro activity against both gram-negative and -positive anaerobes.

* Corresponding author. Mailing address: Department of Pathology, HO83, Penn State Hershey Medical Center, 500 University Dr., Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu.

Antimicrobial Agents and Chemotherapy, March 2003, p. 1143-1147, Vol. 47, No. 3
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.3.1143-1147.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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