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Antimicrobial Agents and Chemotherapy, March 2003, p. 1161-1164, Vol. 47, No. 3
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.3.1161-1164.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

In Vitro Effects of Ciprofloxacin and Roxithromycin on Apoptosis of Jurkat T Lymphocytes

Yong-Taek Jun,1 Hee-Jung Kim,2 Min-Jin Song,2 Ji-Hyang Lim,3 Dong-Gun Lee,1 Kyung-Ja Han,3 Su-Mi Choi,1 Jin-Hong Yoo,1 Wan-Shik Shin,1 and Jung-Hyun Choi1*

Division of Infectious Diseases, Department of Internal Medicine,1 Clinical Research Institute,2 Department of Clinical Pathology, College of Medicine, Catholic University of Korea, Seoul, Korea3

Received 8 November 2001/ Returned for modification 2 September 2002/ Accepted 15 November 2002

Ciprofloxacin (CPFX) and roxithromycin (RXM) induced apoptosis of activated Jurkat T cells in vitro. CPFX showed concentration-dependent acceleration of apoptosis of activated Jurkat T cells by enhancing the expression of FasL and activities of caspase-3 and -8. RXM accelerated cell death, enhanced expression of FasL and caspase-3 but not caspase-8, and did not show the concentration dependency.

* Corresponding author. Mailing address: Department of Internal Medicine, St. Mary's Hospital, 62 Yoido-Dong, Youngdeungpo-Gu, Seoul, 150-010, Korea. Phone: 82-2-3779-2048 and 82-2-3779-1338. Fax: 82-2-780-3132. E-mail: cmcjh{at}catholic.ac.kr.

Antimicrobial Agents and Chemotherapy, March 2003, p. 1161-1164, Vol. 47, No. 3
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.3.1161-1164.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Koziel, R., Zablocki, K., Duszynski, J. (2006). Calcium signals are affected by ciprofloxacin as a consequence of reduction of mitochondrial DNA content in jurkat cells.. Antimicrob. Agents Chemother. 50: 1664-1671 [Abstract] [Full Text]  
  • Choi, J.-H., Song, M.-J., Kim, S.-H., Choi, S.-M., Lee, D.-G., Yoo, J.-H., Shin, W.-S. (2003). Effect of Moxifloxacin on Production of Proinflammatory Cytokines from Human Peripheral Blood Mononuclear Cells. Antimicrob. Agents Chemother. 47: 3704-3707 [Abstract] [Full Text]  


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