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Antimicrobial Agents and Chemotherapy, April 2003, p. 1391-1394, Vol. 47, No. 4
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.4.1391-1394.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of Piperaquine and Other 4-Aminoquinolines against Clinical Isolates of Plasmodium falciparum in Cameroon

Leonardo K. Basco1* and Pascal Ringwald2

Unité de Recherche "Paludologie Afro-tropicale," Institut de Recherche pour le Développement (IRD)-Laboratoire de Recherche sur le Paludisme, Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), Yaoundé, Cameroon,1 Cluster of Communicable Diseases, Surveillance and Response, Emerging Public Health Risks including Drug Resistance, World Health Organization, Geneva, Switzerland2

Received 12 July 2002/ Returned for modification 2 December 2002/ Accepted 24 January 2003

The spread of chloroquine-resistant Plasmodium falciparum calls for a constant search for new drugs. The in vitro activity of piperaquine, a new Chinese synthetic drug belonging to the bisquinolines, was evaluated in 103 fresh clinical isolates of P. falciparum in Cameroon, Central Africa, and compared with that of other 4-aminoquinoline and Mannich base derivatives and dihydroartemisinin. Piperaquine was highly active (geometric mean 50% inhibitory concentration, 38.9 nmol/liter; range, 7.76 to 78.3 nmol/liter) and equally active (P > 0.05) against the chloroquine-sensitive and the chloroquine-resistant isolates. There was a significant but low correlation of response between chloroquine and piperaquine (r = 0.257, P < 0.05). These results suggest that further development of piperaquine, in combination with dihydroartemisinin, holds promise for use in chloroquine-resistant regions of endemicity.

* Corresponding author. Mailing address: OCEAC, B.P. 288, Yaoundé, Cameroon. Phone: 237 223 22 32. Fax: 237 223 00 61. E-mail address: lkbasco{at}yahoo.fr.

Antimicrobial Agents and Chemotherapy, April 2003, p. 1391-1394, Vol. 47, No. 4
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.4.1391-1394.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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