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Antimicrobial Agents and Chemotherapy, April 2003, p. 1403-1406, Vol. 47, No. 4
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.4.1403-1406.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Activities of ABT-773 against Listeria monocytogenes and Coryneform Bacteria of Clinical Interest

María del Carmen Conejo,1 Luis Martínez-Martínez,1,2* Álvaro Pascual,1,2 Ana Isabel Suárez,2 and Evelio J. Perea1,2

Department of Microbiology, School of Medicine,1 University Hospital Virgen Macarena, University of Seville, Seville, Spain2

Received 29 July 2002/ Returned for modification 9 October 2002/ Accepted 31 December 2002

The in vitro activities of ABT-773 were evaluated against 15 Listeria monocytogenes strains and 196 coryneform bacteria isolated from clinical samples. One hundred percent of the L. monocytogenes strains were inhibited by <=0.015 µg of ABT-773/ml. MICs of ABT-773 (µg/ml) at which 50% of the isolates tested were inhibited (MIC50s) and MIC90s for other organisms were 0.125 and 0.5 (Corynebacterium amycolatum), 1 and >32 (Corynebacterium jeikeium), 0.03 and >32 (Corynebacterium minutissimum), >32 and >32 (Corynebacterium pseudodiphtheriticum and Corynebacterium urealyticum), 0.125 and >32 (Corynebacterium striatum), and 0.03 and 0.5 (Rhodococcus equi), respectively.

* Corresponding author. Mailing address: Department of Microbiology, School of Medicine, University of Seville, Apdo. 914, 41080 Seville, Spain. Phone: 34 95 500 8287. Fax: 34 95 437 7413. E-mail: lmartin{at}us.es.

Antimicrobial Agents and Chemotherapy, April 2003, p. 1403-1406, Vol. 47, No. 4
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.4.1403-1406.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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