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Antimicrobial Agents and Chemotherapy, April 2003, p. 1416-1418, Vol. 47, No. 4
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.4.1416-1418.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

In Vitro Synergy of Caspofungin and Itraconazole against Aspergillus spp.: MIC versus Minimal Effective Concentration End Points

Itamar Shalit,1,2 Yona Shadkchan,2 Zmira Samra,2,3 and Nir Osherov2*

Schneider Children's Medical Center of Israel,1 Sackler School of Medicine,2 Rabin Medical Center, Petach Tikvah, Tel Aviv University, Tel Aviv, Israel3

Received 22 August 2002/ Returned for modification 28 October 2002/ Accepted 21 January 2003

Caspofungin and itraconazole were studied alone and in combination against 31 clinical isolates of Aspergillus spp. according to NCCLS M38-P guidelines. MICs and microscopic minimal effective concentrations (MECs) were recorded, and synergy was calculated by using both end points. Synergy or synergy to additivity was found in 30 of 31 isolates by using MIC end points. With MEC end points no synergy was found and indifference was detected in 26 of 31 strains.

* Corresponding author. Mailing address: Department of Human Microbiology, Sackler School of Medicine, Tel Aviv University, Ramat-Aviv 69978, Tel Aviv, Israel. Phone: 972-3-640-9599. Fax: 972-3-640-9160. E-mail: nosherov{at}post.tau.ac.il.

Antimicrobial Agents and Chemotherapy, April 2003, p. 1416-1418, Vol. 47, No. 4
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.4.1416-1418.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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