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Antimicrobial Agents and Chemotherapy, April 2003, p. 1439-1442, Vol. 47, No. 4
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.4.1439-1442.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Tissue Penetration by Ertapenem, a Parenteral Carbapenem Administered Once Daily, in Suction-Induced Skin Blister Fluid in Healthy Young Volunteers

T. Laethem,1* I. De Lepeleire,1 J. McCrea,2 J. Zhang,2 A. Majumdar,2 D. Musson,2 D. Rogers,2 S. Li,2 M. Guillaume,3 A. Parneix-Spake,3 and P. Deutsch2

Merck & Co., Inc., Brussels, Belgium,1 Merck & Co., Inc., Rahway, New Jersey,2 Aster Cephac, Paris, France3

Received 21 June 2002/ Returned for modification 22 October 2002/ Accepted 23 December 2002

The penetration of 1 g of intravenous ertapenem once daily for 3 days in suction-induced skin blisters was evaluated. Ten forearm blisters were formed (n = 12) 12 h prior to the last dose. Concentrations of ertapenem in blister fluid exceeded 4 µg/ml (the MIC at which 90% of the isolates tested are eliminated) for the entire dosing interval. The area under the concentration-time curve for 0 to 24 h ratio of blister fluid to plasma was 61% (90% confidence interval, 56, 65%) suggesting good blister penetration.

* Corresponding author. Mailing address: Department of Clinical Pharmacology, MSD, Clos du Lynx 5, 1200 Brussels, Belgium. Phone: 32 2 77 66 209. Fax: 32 2 77 66 478. E-mail: tine_laethem{at}merck.com.

Antimicrobial Agents and Chemotherapy, April 2003, p. 1439-1442, Vol. 47, No. 4
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.4.1439-1442.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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