This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lunardi, F.
Right arrow Articles by Santos, A. R. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lunardi, F.
Right arrow Articles by Santos, A. R. S.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, April 2003, p. 1449-1451, Vol. 47, No. 4
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.4.1449-1451.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Trypanocidal and Leishmanicidal Properties of Substitution-Containing Chalcones

Fabiane Lunardi,1,2 Michel Guzela,1 Andrea T. Rodrigues,1 Rogério Corrêa,1 Iriane Eger-Mangrich,1,2 Mário Steindel,2 Edmundo C. Grisard,2 Jamil Assreuy,3 João B. Calixto,3 and Adair R. S. Santos4*

Faculdade de Farmácia, Centro de Ciências da Saúde, Universidade do Vale do Itajaí,1 Departamento de Microbiologia e Parasitologia,2 Departamento de Farmacologia,3 Departamento de Ciências Fisiológicas, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil4

Received 21 May 2002/ Returned for modification 2 July 2002/ Accepted 3 January 2003

Ten chalcones were synthesized and tested as potential leishmanicidal and trypanocidal agents. All tested compounds caused concentration-dependent inhibition of the in vitro growth of Leishmania braziliensis and Trypanosoma cruzi with no significant toxic effect towards host macrophages. Our results show that the positions of the substituents seem to be critical for their antiprotozoal activities.

* Corresponding author. Mailing address: Departamento de Ciências Fisiológicas, Universidade Federal de Santa Catarina, Campus Universitário, Trindade, 88.040-900, Florianópolis SC, Brazil. Phone: 55-48-3319444. Fax: 55-48-331-6910. E-mail: arssantos{at}uol.com.br.

Antimicrobial Agents and Chemotherapy, April 2003, p. 1449-1451, Vol. 47, No. 4
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.4.1449-1451.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»