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Antimicrobial Agents and Chemotherapy, June 2003, p. 1943-1947, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.1943-1947.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Activities of Ertapenem, a New Long-Acting Carbapenem, against Penicillin-Sensitive or -Resistant Pneumococci in Experimental Meningitis

P. Cottagnoud,1* M. Pfister,2 M. Cottagnoud,3 F. Acosta,3 and M. G. Täuber4

Department of Internal Medicine, Inselspital,1 Department of Internal Medicine, Spital Bern-Ziegler,3 Institute for Infectious Diseases, University of Bern, Bern, Switzerland,4 Department of Laboratory Medicine and Biopharmaceutical Sciences, University of California, San Francisco, California2

Received 8 July 2002/ Returned for modification 28 December 2002/ Accepted 26 February 2003

The penetration of ertapenem, a new carbapenem with a long half-life, reached 7.1 and 2.4% into inflamed and noninflamed meninges, respectively. Ertapenem had excellent antibacterial activity in the treatment of experimental meningitis due to penicillin-sensitive and -resistant pneumococci, leading to a decrease of 0.69 ± 0.17 and 0.59 ± 0.22 log10 CFU/ml · h, respectively, in the viable cell counts in the cerebrospinal fluid. The efficacy of ertapenem was comparable to that of standard regimens (ceftriaxone monotherapy against the penicillin-sensitive strain and ceftriaxone combined with vancomycin against the penicillin-resistant strain). In vitro, ertapenem in concentrations above the MIC was highly bactericidal against both strains. Even against a penicillin- and quinolone-resistant mutant, ertapenem had similar bactericidal activity in vitro.

* Corresponding author. Mailing address: Department of Internal Medicine, Inselspital, Freiburgstrasse, 3010 Bern, Switzerland. Phone: 41-31-632-34-72. Fax: 41-31-632-38-47. E-mail: pcottagn{at}insel.ch.

Antimicrobial Agents and Chemotherapy, June 2003, p. 1943-1947, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.1943-1947.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Cottagnoud, P., Pfister, M., Acosta, F., Cottagnoud, M., Flatz, L., Kuhn, F., Muller, H.-P., Stucki, A. (2004). Daptomycin Is Highly Efficacious against Penicillin-Resistant and Penicillin- and Quinolone-Resistant Pneumococci in Experimental Meningitis. Antimicrob. Agents Chemother. 48: 3928-3933 [Abstract] [Full Text]  


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