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Antimicrobial Agents and Chemotherapy, June 2003, p. 1948-1951, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.1948-1951.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Efficacy of Albaconazole (UR-9825) in Treatment of Disseminated Scedosporium prolificans Infection in Rabbits

Javier Capilla,¹ Clara Yustes,¹ Emili Mayayo,^2,3 Belkys Fernández,¹ Montserrat Ortoneda,¹ F. Javier Pastor,¹ and Josep Guarro^1*

Unitat de Microbiologia,¹ Unitat de Anatomia Patològica, Facultat de Medicina, Universitat Rovira i Virgili, Reus,² Servei Patologia, Hospital Universitari de Tarragona Joan XXIII, Tarragona, Spain³

Received 25 October 2002/ Returned for modification 22 November 2002/ Accepted 3 February 2003

There are no effective therapeutics for treating invasive Scedosporium prolificans infections. Doses of 15, 25, and 50 mg/kg of body weight/day for the new triazole albaconazole (ABC) were evaluated in an immunocompetent rabbit model of systemic infection with this mold. Treatments were begun 1 day after challenge and given for 10 days. ABC at any dose was more effective than amphotericin B (AMB) at 0.8 mg/kg/day at clearing S. prolificans from tissue (P < 0.007). The percentages of survival at 25 mg of ABC/kg/day were similar to those obtained with AMB. Rabbits showed 100% survival when they were treated with 50 mg of ABC per kg (P < 0.0001 versus control group), and only this dosage was able to reduce tissue burden significantly in the five organs studied, i.e., spleen, kidneys, liver, lungs, and brain.

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* Corresponding author. Mailing address: Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, 21 Sant Llorenç Street, 43201 Reus, Spain. Phone: 977 759 359. Fax: 977 759 322. E-mail: umb{at}fmcs.urv.es.

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Antimicrobial Agents and Chemotherapy, June 2003, p. 1948-1951, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.1948-1951.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

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