This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hendley, J. O.
Right arrow Articles by Ashe, K. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hendley, J. O.
Right arrow Articles by Ashe, K. M.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, June 2003, p. 1988-1990, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.1988-1990.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Eradication of Resident Bacteria of Normal Human Skin by Antimicrobial Ointment

J. Owen Hendley* and Kathleen M. Ashe

Department of Pediatrics, University of Virginia Health System, Charlottesville, Virginia

Received 14 November 2002/ Returned for modification 22 January 2003/ Accepted 10 March 2003

The application of a topical triple-antibiotic ointment (containing neomycin, polymyxin, and bacitracin) eradicated resident bacteria through 25 layers of the stratum corneum and prevented repopulation of bacteria overnight but not at 1 week. Through 15 layers, mupirocin had some effect, whereas a double-antibiotic ointment had none. The reservoir of resident bacteria in the sebaceous glands is not affected by a topical antibiotic.

* Corresponding author. Mailing address: Department of Pediatrics, University of Virginia Health System, Box 800386, Charlottesville, VA 22908. Phone: (434) 924-2570. Fax: (434) 924-2205. E-mail: JOH{at}virginia.edu.

Antimicrobial Agents and Chemotherapy, June 2003, p. 1988-1990, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.1988-1990.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Karpanen, T. J., Worthington, T., Conway, B. R., Hilton, A. C., Elliott, T. S. J., Lambert, P. A. (2009). Permeation of Chlorhexidine from Alcoholic and Aqueous Solutions within Excised Human Skin. Antimicrob. Agents Chemother. 53: 1717-1719 [Full Text]  
  • Karpanen, T. J., Worthington, T., Hendry, E. R., Conway, B. R., Lambert, P. A. (2008). Antimicrobial efficacy of chlorhexidine digluconate alone and in combination with eucalyptus oil, tea tree oil and thymol against planktonic and biofilm cultures of Staphylococcus epidermidis. J Antimicrob Chemother 62: 1031-1036 [Abstract] [Full Text]  
  • Karpanen, T. J., Worthington, T., Conway, B. R., Hilton, A. C., Elliott, T. S. J., Lambert, P. A. (2008). Penetration of Chlorhexidine into Human Skin. Antimicrob. Agents Chemother. 52: 3633-3636 [Abstract] [Full Text]  
  • (2005). Part 14: First Aid. Circulation 112: IV-196-IV-203 [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»