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Antimicrobial Agents and Chemotherapy, June 2003, p. 1991-1994, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.1991-1994.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Stability and Antibacterial Activity of Cefepime during Continuous Infusion

Pål F. Sprauten,1,2 Paul M. Beringer,2* Stan G. Louie,2 Timothy W. Synold,3 and Mark A. Gill2

University of Oslo, Oslo, Norway,1 University of Southern California, Los Angeles,2 City of Hope, Duarte, California3

Received 3 October 2002/ Returned for modification 23 January 2003/ Accepted 18 March 2003

The stability of cefepime during simulated continuous infusion was determined with a motorized portable infusion pump worn over a period of 24 to 36 h. Susceptibility testing on cefepime solutions over time indicates that the degradation products do not exhibit antibacterial activity. Cefepime stability at 24 h following continuous infusion was 94.3% ± 1.0%, which supports the use of continuous infusion.

* Corresponding author. Mailing address: USC School of Pharmacy, 1985 Zonal Ave., Los Angeles, CA 90089-9121. Phone: (323) 442-1402. Fax: (626) 628-3024. E-mail: beringer{at}usc.edu.

Antimicrobial Agents and Chemotherapy, June 2003, p. 1991-1994, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.1991-1994.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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