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Antimicrobial Agents and Chemotherapy, June 2003, p. 2009-2011, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.2009-2011.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Molecular Characterization of Isoniazid-Resistant Mycobacterium tuberculosis Clinical Isolates in Lithuania

Daiva Bakonyte,1 Aurelija Baranauskaite,1 Jurate Cicenaite,2 Anaida Sosnovskaja,2 and Petras Stakenas1*

Laboratory of Immunology, Institute of Biotechnology, Vilnius 2028,1 National Tuberculosis Reference Laboratory, The Republican Hospital of Tuberculosis and Lung Diseases, Vilnius 2040, Lithuania2

Received 21 October 2002/ Returned for modification 30 December 2002/ Accepted 10 March 2003

Mutations at codon 315 of the katG gene were detected in 312 of 364 (85.7%) isoniazid-resistant Mycobacterium tuberculosis isolates. Seven of 52 (13.5%) isoniazid-resistant isolates with the wild-type Ser315 codon and 10 of 52 (19.2%) isoniazid-resistant isolates with a mutated katG allele had mutation -15C->T in the promoter of the mabA-inhA operon.

* Corresponding author. Mailing address: Institute of Biotechnology, V. Graiciuno 8., LT-2028 Vilnius, Lithuania. Phone: 370 5 2602124. Fax: 370 5 2602116. E-mail: pstak{at}ibt.lt.

Antimicrobial Agents and Chemotherapy, June 2003, p. 2009-2011, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.2009-2011.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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