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Antimicrobial Agents and Chemotherapy, July 2003, p. 2307-2309, Vol. 47, No. 7
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.7.2307-2309.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Nonsense Mutations in the lsa-Like Gene in Enterococcus faecalis Isolates Susceptible to Lincosamides and Streptogramins A

Julia Dina, Brigitte Malbruny, and Roland Leclercq*

Service de Microbiologie, CHU Côte de Nacre, 14033 Caen Cedex, France

Received 30 January 2003/ Accepted 21 March 2003

The lsa gene confers intrinsic resistance to lincosamides and streptogramins A in Enterococcus faecalis, probably by active efflux. The lsa-like genes of two clinical isolates of E. faecalis susceptible to lincosamides and dalfopristin contained mutations that produced premature termination codons. Revertant mutants were obtained by selection on agar plates containing clindamycin.

* Corresponding author. Mailing address: CHU de Caen, Service de Microbiologie, Avenue Côte de Nacre, 14033 Caen Cedex, France. Phone: 33 2 31 06 45 72. Fax: 33 2 31 06 45 73. E-mail: leclercq-r{at}chu-caen.fr.

Antimicrobial Agents and Chemotherapy, July 2003, p. 2307-2309, Vol. 47, No. 7
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.7.2307-2309.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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