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Antimicrobial Agents and Chemotherapy, August 2003, p. 2619-2623, Vol. 47, No. 8
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.8.2619-2623.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Oral Lactoferrin Treatment of Experimental Oral Candidiasis in Mice

Natsuko Takakura,1,2* Hiroyuki Wakabayashi,1 Hiroko Ishibashi,2 Susumu Teraguchi,1 Yoshitaka Tamura,1 Hideyo Yamaguchi,2 and Shigeru Abe2

Nutritional Science Laboratory, Morinaga Milk Industry Co., Ltd., Kanagawa,1 Teikyo University Institute of Medical Mycology, Tokyo, Japan2

Received 7 November 2002/ Returned for modification 17 February 2003/ Accepted 10 May 2003

We assessed the potential of lactoferrin (LF), a multifunctional milk protein, for treatment of oral candidiasis with immunosuppressed mice, which have local symptoms characteristic of oral thrush. Oral administration of bovine LF in drinking water starting 1 day before the infection significantly reduced the number of Candida albicans in the oral cavity and the score of lesions on the tongue on day 7 after the inoculation. The symptomatic effect of LF was confirmed by macroscopic and microscopic observations of the tongue's surface. Similar effects were also observed upon administration of LF pepsin hydrolysate, but not lactoferricin B, an antimicrobial peptide of LF. The anticandidal activity of LF was evident on administration either in drinking water or by intragastric intubation with a stomach tube. These results suggest that the effect of LF in this oral candidiasis model is not due to direct antifungal action. In conclusion, LF could have potential as a food component supporting antifungal drug treatment.

* Corresponding author. Mailing address: Nutritional Science Laboratory, Morinaga Milk Industry Co., Ltd., 5-1-83 Higashihara, Zama, Kanagawa 228-8583, Japan. Phone: 81-46-252-3045. Fax: 81-46-252-3049. E-mail: n-takakr{at}morinagamilk.co.jp.

Antimicrobial Agents and Chemotherapy, August 2003, p. 2619-2623, Vol. 47, No. 8
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.8.2619-2623.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Wakabayashi, H., Yamauchi, K., Kobayashi, T., Yaeshima, T., Iwatsuki, K., Yoshie, H. (2009). Inhibitory Effects of Lactoferrin on Growth and Biofilm Formation of Porphyromonas gingivalis and Prevotella intermedia. Antimicrob. Agents Chemother. 53: 3308-3316 [Abstract] [Full Text]  
  • Wakabayashi, H., Takakura, N., Yamauchi, K., Tamura, Y. (2006). Modulation of Immunity-Related Gene Expression in Small Intestines of Mice by Oral Administration of Lactoferrin. CVI 13: 239-245 [Abstract] [Full Text]  
  • Takakura, N., Wakabayashi, H., Ishibashi, H., Yamauchi, K., Teraguchi, S., Tamura, Y., Yamaguchi, H., Abe, S. (2004). Effect of orally administered bovine lactoferrin on the immune response in the oral candidiasis murine model. J Med Microbiol 53: 495-500 [Abstract] [Full Text]  


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