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Antimicrobial Agents and Chemotherapy, August 2003, p. 2646-2648, Vol. 47, No. 8
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.8.2646-2648.2003

In Vitro Susceptibilities of Seven Leptospira Species to Traditional and Newer Antibiotics

Duane R. Hospenthal* and Clinton K. Murray

Infectious Disease Service, Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, Texas

Received 26 December 2002/ Returned for modification 27 March 2003/ Accepted 12 May 2003

Human leptospirosis is generally treated with penicillin or doxycycline. We studied the susceptibilities of 11 serovars (seven species) of Leptospira to 14 antibiotics. With the exception of chloramphenicol, all tested agents were at least as potent as penicillin and doxycycline, with the macrolide and ketolide drugs producing the lowest MICs (and minimal bactericidal concentrations).

* Corresponding author. Mailing address: Brooke Army Medical Center, Infectious Disease (MCHE-MDI), 3851 Roger Brooke Dr., Fort Sam Houston, TX 78234. Phone: (210) 916-4355. Fax: (210) 916-0388. E-mail: Duane.Hospenthal{at}amedd.army.mil.

Antimicrobial Agents and Chemotherapy, August 2003, p. 2646-2648, Vol. 47, No. 8
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.8.2646-2648.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • van de Maele, I., Claus, A., Haesebrouck, F., Daminet, S. (2008). Leptospirosis in dogs: a review with emphasis on clinical aspects. Vet Rec. 163: 409-413 [Abstract] [Full Text]  
  • Ressner, R. A., Griffith, M. E., Beckius, M. L., Pimentel, G., Miller, R. S., Mende, K., Fraser, S. L., Galloway, R. L., Hospenthal, D. R., Murray, C. K. (2008). Antimicrobial Susceptibilities of Geographically Diverse Clinical Human Isolates of Leptospira. Antimicrob. Agents Chemother. 52: 2750-2754 [Abstract] [Full Text]  
  • Moon, J. E., Ellis, M. C., Griffith, M. E., Hawley, J. S., Rivard, R. G., McCall, S., Hospenthal, D. R., Murray, C. K. (2006). Efficacy of Macrolides and Telithromycin against Leptospirosis in a Hamster Model.. Antimicrob. Agents Chemother. 50: 1989-1992 [Abstract] [Full Text]  
  • MURRAY, C. K., ELLIS, M. W., HOSPENTHAL, D. R. (2004). SUSCEPTIBILITY OF LEPTOSPIRA SEROVARS TO ANTIMALARIAL AGENTS. Am J Trop Med Hyg 71: 685-686 [Abstract] [Full Text]  
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  • Murray, C. K., Hospenthal, D. R. (2004). Broth Microdilution Susceptibility Testing for Leptospira spp.. Antimicrob. Agents Chemother. 48: 1548-1552 [Abstract] [Full Text]  


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