This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dailey, C. F.
Right arrow Articles by Gibson, J. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dailey, C. F.
Right arrow Articles by Gibson, J. K.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, August 2003, p. 2655-2658, Vol. 47, No. 8
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.8.2655-2658.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Efficacy of Linezolid plus Rifampin in an Experimental Model of Methicillin-Susceptible Staphylococcus aureus Endocarditis

Charlene F. Dailey,1 Paul J. Pagano,1 Lewis V. Buchanan,1 Jennifer A. Paquette,1 Joseph V. Haas,2 and John K. Gibson1*

Pharmacology,1 Non-Clinical Statistics, Pfizer, Kalamazoo, Michigan 490012

Received 14 January 2003/ Returned for modification 3 March 2003/ Accepted 7 May 2003

The efficacy of linezolid, alone or in combination with rifampin, against methicillin-susceptible Staphylococcus aureus in rabbits with experimental endocarditis was investigated. Linezolid (50 or 75 mg/kg of body weight), rifampin, and linezolid (25, 50, or 75 mg/kg) plus rifampin produced statistically significant reductions in bacterial counts compared with those in untreated controls. Plasma or valvular vegetation levels of linezolid in the groups treated with the linezolid-rifampin combination were similar to those in the respective linezolid-only treatment groups. At therapeutic levels of linezolid, rifampin resistance was not observed. The results from this experimental model of endocarditis suggest that while rifampin did not provide synergy to the linezolid dosing, it did not antagonize the efficacy of linezolid.

* Corresponding author. Mailing address: Pfizer, 700 Chesterfield Pkwy, AA4A, Chesterfield, MO 63017. Phone: (636) 247-7078. Fax: (636) 247-6987. E-mail: John.K.Gibson{at}pfizer.com.

Antimicrobial Agents and Chemotherapy, August 2003, p. 2655-2658, Vol. 47, No. 8
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.8.2655-2658.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Nguyen, H. M., Graber, C. J. (2009). Limitations of antibiotic options for invasive infections caused by methicillin-resistant Staphylococcus aureus: is combination therapy the answer?. J Antimicrob Chemother 0: dkp377v1-dkp377 [Abstract] [Full Text]  
  • Perlroth, J., Kuo, M., Tan, J., Bayer, A. S., Miller, L. G. (2008). Adjunctive Use of Rifampin for the Treatment of Staphylococcus aureus Infections: A Systematic Review of the Literature. Arch Intern Med 168: 805-819 [Abstract] [Full Text]  
  • Falagas, M. E., Manta, K. G., Ntziora, F., Vardakas, K. Z. (2006). Linezolid for the treatment of patients with endocarditis: a systematic review of the published evidence. J Antimicrob Chemother 58: 273-280 [Abstract] [Full Text]  
  • Jacqueline, C., Caillon, J., Grossi, O., Le Mabecque, V., Miegeville, A.-F., Bugnon, D., Batard, E., Potel, G. (2006). In Vitro and In Vivo Assessment of Linezolid Combined with Ertapenem: a Highly Synergistic Combination against Methicillin-Resistant Staphylococcus aureus.. Antimicrob. Agents Chemother. 50: 2547-2549 [Abstract] [Full Text]  
  • Athanassopoulos, G., Pefanis, A., Sakka, V., Iliopoulos, D., Perrea, D., Giamarellou, H. (2006). Linezolid in Prophylaxis against Experimental Aortic Valve Endocarditis Due to Streptococcus oralis or Enterococcus faecalis. Antimicrob. Agents Chemother. 50: 654-657 [Abstract] [Full Text]  
  • Jacqueline, C., Navas, D., Batard, E., Miegeville, A.-F., Le Mabecque, V., Kergueris, M.-F., Bugnon, D., Potel, G., Caillon, J. (2005). In Vitro and In Vivo Synergistic Activities of Linezolid Combined with Subinhibitory Concentrations of Imipenem against Methicillin-Resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 49: 45-51 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»