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Antimicrobial Agents and Chemotherapy, August 2003, p. 2699-2702, Vol. 47, No. 8
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.8.2699-2702.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Antimicrobial Susceptibility and Macrolide Resistance Inducibility of Streptococcus pneumoniae Carrying erm(A), erm(B), or mef(A)

George A. Syrogiannopoulos,1* Ioanna N. Grivea,1 Lois M. Ednie,2 Bülent Bozdogan,2 George D. Katopodis,1 Nicholas G. Beratis,1 Todd A. Davies,2 and Peter C. Appelbaum2

Department of Pediatrics, General University Hospital, University of Patras, School of Medicine, Patras, Greece,1 Department of Pathology, The Milton S. Hershey Medical Center, Hershey, Pennsylvania2

Received 30 September 2002/ Returned for modification 26 February 2003/ Accepted 5 May 2003

Erythromycin-resistant Streptococcus pneumoniae isolates from young carriers were tested for their antimicrobial susceptibility; additionally, inducibility of macrolide and clindamycin resistance was investigated in pneumococci carrying erm(A), erm(B), or mef(A). Of 125 strains tested, 101 (81%) were multidrug resistant. Different levels of induction were observed with erythromycin, miocamycin, and clindamycin in erm(B) strains; however, in erm(A) strains only erythromycin was an inducer. Induction did not affect macrolide MICs in mef(A) strains.

* Corresponding author. Mailing address: Department of Pediatrics, Division of Infectious Disease, University of Patras, School of Medicine, 265 04 Rion, Patras, Greece. Phone: 30-2610-993948. Fax: 30-2610-994533. E-mail: syrogian{at}med.upatras.gr.

Antimicrobial Agents and Chemotherapy, August 2003, p. 2699-2702, Vol. 47, No. 8
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.8.2699-2702.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Camilli, R., Del Grosso, M., Iannelli, F., Pantosti, A. (2008). New Genetic Element Carrying the Erythromycin Resistance Determinant erm(TR) in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 52: 619-625 [Abstract] [Full Text]  


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