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Antimicrobial Agents and Chemotherapy, September 2003, p. 2978-2980, Vol. 47, No. 9
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.9.2978-2980.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

New Plasmid-Borne Antibiotic Resistance Gene Cluster in Pasteurella multocida

Corinna Kehrenberg,1 Nga Thi Thu Tham,1,2 and Stefan Schwarz1*

Institut für Tierzucht, Bundesforschungsanstalt für Landwirtschaft (FAL), 31535 Neustadt-Mariensee, Germany,1 Institute of Biotechnology, National Center for Science and Technology, 10000 Hanoi, Vietnam2

Received 27 January 2003/ Returned for modification 7 April 2003/ Accepted 17 May 2003

A new antibiotic resistance gene cluster comprising genes for sulfonamide (sul2), streptomycin (strA-strB), and tetracycline [tetR-tet(H)] resistance was detected on plasmid pVM111 from Pasteurella multocida. The tetR-tet(H) gene region was inserted between sul2 and strA, possibly by illegitimate recombination. Two potential recombination sites of 18 and 25 bp were identified.

* Corresponding author. Mailing address: Institut für Tierzucht der Bundesforschungsanstalt für Landwirtschaft (FAL), Höltystr. 10, 31535 Neustadt-Mariensee, Germany. Phone: 49-5034-871-241. Fax: 49-5034-871-246. E-mail: stefan.schwarz{at}fal.de.

Antimicrobial Agents and Chemotherapy, September 2003, p. 2978-2980, Vol. 47, No. 9
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.9.2978-2980.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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