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Antimicrobial Agents and Chemotherapy, September 2003, p. 2987-2989, Vol. 47, No. 9
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.9.2987-2989.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Measurement of Cefaclor and Amoxicillin-Clavulanic Acid Levels in Middle-Ear Fluid in Patients with Acute Otitis Media

F. Scaglione,1* D. Caronzolo,1 J. P. Pintucci,2 and F. Fraschini1

University of Milan, Milan,1 Vimercate Hospital, Vimercate, Italy2

Received 3 April 2003/ Returned for modification 31 May 2003/ Accepted 23 June 2003

Concentrations of cefaclor (CFC) or amoxicillin-clavulanic acid (AMX/CA) in middle-ear fluid collected preserving the stability and clearing the cell contents has been compared to those obtained using the traditional method. Sixty-seven children with effusive otitis media were treated orally with CFC (20 mg/kg of body weight) or AMX/CA (20 mg/kg) (4:1 ratio). The concentrations in cell-free fluid (C-) appear higher than those in the total fluid (C+) (as assayed traditionally).

* Corresponding author. Mailing address: Faculty of Medicine, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy. Phone: 39-0250317073. Fax: 39-0250317050. E-mail: francesco.scaglione{at}unimi.it.

Antimicrobial Agents and Chemotherapy, September 2003, p. 2987-2989, Vol. 47, No. 9
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.9.2987-2989.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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