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Antimicrobial Agents and Chemotherapy, September 2003, p. 2997-3001, Vol. 47, No. 9
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.9.2997-3001.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Novel Pseudomonas aeruginosa Gene That Suppresses Tolerance to Carbapenems

Kazuko Taniguchi,1 Tsuneko Ono,2* Keiji Murakami,1 Darija Viducic,1 Sizuo Kayama,1 Katsuhiko Hirota,1 Ken Nemoto,1 and Yoichiro Miyake1

Department of Microbiology, Tokushima University School of Dentistry, Tokushima 770-8504,1 Major in Laboratory Science, Tokushima University School of Health Science, Tokushima 770-8509, Japan2

Received 23 January 2003/ Returned for modification 24 March 2003/ Accepted 20 June 2003

A biapenem-tolerant mutant of Pseudomonas aeruginosa was isolated by Tn1737KH insertion. The survival of the mutant 3 h after the addition of biapenem was about 1,000 times greater than that of the wild type. The mutant was also tolerant to other biapenems, such as imipenem, panipenem, and meropenem.

* Corresponding author. Mailing address: Major in Laboratory Science, Tokushima University School of Health Science, Tokushima 770-8509, Japan. Phone: 81-88-633-9061. Fax: 81-88-633-9061. E-mail: ono{at}medsci.medsci.tokushima-u.ac.jp.

Antimicrobial Agents and Chemotherapy, September 2003, p. 2997-3001, Vol. 47, No. 9
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.9.2997-3001.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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