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Antimicrobial Agents and Chemotherapy, September 2003, p. 3012-3014, Vol. 47, No. 9
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.9.3012-3014.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Postantibiotic Effects of Daptomycin against 14 Staphylococcal and Pneumococcal Clinical Isolates

G. A. Pankuch,1 M. R. Jacobs,2 and P. C. Appelbaum1*

Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033,1 Department of Pathology, Case Western Reserve University, Cleveland, Ohio 441062

Received 27 February 2003/ Returned for modification 25 April 2003/ Accepted 2 June 2003

Daptomycin mean staphylococcal postantibiotic effects (PAEs) were 1.1 to 6.2 h, with a mean of 2.5 h. The mean pneumococcal PAEs were 1.7 h, ranging between 1.0 and 2.5 h. The staphylococcal and pneumococcal postantibiotic sub-MIC effects at 0.4 times the MIC ranged from 3.0 to >12.0 h and 1.9 to >12.0 h, respectively.

* Corresponding author. Mailing address: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu.

Antimicrobial Agents and Chemotherapy, September 2003, p. 3012-3014, Vol. 47, No. 9
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.9.3012-3014.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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