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Antimicrobial Agents and Chemotherapy, September 2003, p. 3030-3033, Vol. 47, No. 9
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.9.3030-3033.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Roles of TolC-Dependent Multidrug Transporters of Escherichia coli in Resistance to ß-Lactams

Kunihiko Nishino,1,2,3,4 Junko Yamada,1,2,3 Hidetada Hirakawa,1,2,3 Takahiro Hirata,1,2,3 and Akihito Yamaguchi1,2,3*

Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki,1 CREST, Japan Science and Technology Corporation, Osaka 567-0047,2 Faculty of Pharmaceutical Science,3 Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan4

Received 10 March 2003/ Returned for modification 7 May 2003/ Accepted 18 June 2003

AcrAB exports some ß-lactam antibiotics in the periplasm out of cells via an outer-membrane channel, TolC. It has been reported that eight drug transporters in Escherichia coli cooperate with TolC. In this study, the roles of the drug exporters of E. coli in ß-lactam resistance were examined. We found that five of five resistance-nodulation-cell division-type drug exporters confer ß-lactam antibiotic resistance, while no other drug exporters confer any ß-lactam resistance even when they cooperate with TolC.

* Corresponding author. Mailing address: Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan. Phone: 81-6-6879-8545. Fax: 81-6-6879-8549. E-mail: akihito{at}sanken.osaka-u.ac.jp.

Antimicrobial Agents and Chemotherapy, September 2003, p. 3030-3033, Vol. 47, No. 9
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.9.3030-3033.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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