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Antimicrobial Agents and Chemotherapy, October 2004, p. 4054-4055, Vol. 48, No. 10
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.10.4054-4055.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Novel Resistance-Nodulation-Cell Division Efflux System AdeDE in Acinetobacter Genomic DNA Group 3

Sze-Lok Chau,1 Yiu-Wai Chu,1* and Elizabeth T. S. Houang1

Department of Microbiology, The Chinese University of Hong KongHong Kong Special Administrative Region, People's Republic of China

Received 15 December 2003/ Returned for modification 3 March 2004/ Accepted 26 June 2004

Resistance-nodulation-cell division type efflux pump AdeDE was identified in acinetobacters belonging to genomic DNA group 3. Inactivation of adeE showed that it may be responsible for reduced susceptibility to amikacin, ceftazidime, chloramphenicol, ciprofloxacin, erythromycin, ethidium bromide, meropenem, rifampin, and tetracycline. However, unlike what was found for other similar efflux systems, the open reading frame for the outer membrane component was not found downstream of the adeDE gene cluster.

* Corresponding author. Mailing address: Public Health Laboratory Centre, Department of Health, Hong Kong Special Administrative Region, People's Republic of China. Phone: 852 2319 8685. Fax: 852 2776 1446. E-mail: so_micro4{at}dh.gov.hk.

Antimicrobial Agents and Chemotherapy, October 2004, p. 4054-4055, Vol. 48, No. 10
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.10.4054-4055.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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